Symbol Name ID |
Stat5b
signal transducer and activator of transcription 5B MGI:103035 |
Darker colors indicate more annotations |
Human Phenotypes | Increased circulating IgE level |
Celiac disease |
Thyroiditis |
Eczematoid dermatitis |
Recurrent infections |
Disease(s) Associated with STAT5B | |||||
growth hormone insensitivity syndrome with immune dysregulation 2 |
Mouse Phenotypes | abnormal neutrophil differentiation |
decreased T cell proliferation |
decreased thymocyte number |
enlarged spleen |
abnormal leukopoiesis |
abnormal double-negative T cell morphology |
decreased neutrophil cell number |
abnormal lymphocyte cell number |
decreased NK cell number |
abnormal T cell subpopulation ratio |
decreased CD8-positive, alpha-beta T cell number |
decreased lymphocyte cell number |
decreased monocyte cell number |
decreased leukocyte cell number |
abnormal lymphocyte morphology |
decreased splenocyte number |
abnormal neutrophil physiology |
impaired natural killer cell mediated cytotoxicity |
increased circulating interleukin-17 level |
increased interleukin-17 secretion |
abnormal acute inflammation |
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Availability | Mouse Genotype | |||||||||||||||||||||
Stat5btm1Hwd/Stat5btm1Hwd | ||||||||||||||||||||||
Stat5btm1Mam/Stat5btm1Mam Tg(Lck-cre)I57Jxm/0 (conditional) |
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Stat5btm1Mam/Stat5btm1Mam Tg(Cd4-cre)1Cwi/0 (conditional) |
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Stat5btm1Mam/Stat5btm1Mam Tg(Mx1-cre)1Cgn/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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